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Pandit, Bibhas
- Protective effect of Cod Liver Oil in Experimentally Induced Gastric Ulceration in Rats
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Authors
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1 Department of Pharmacology, PRIST University, Thanjavur-614904, Tamilnadu, IN
2 Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh, Pin-493111, IN
1 Department of Pharmacology, PRIST University, Thanjavur-614904, Tamilnadu, IN
2 Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh, Pin-493111, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 5-10Abstract
Background: Gastric ulcer is a life style disease, observed when gastric mucosa is exposed to the acid-pepsin mixture (APM) for prolonged period of time. The reason to undertake the present study is based on the scientific evidence that the cod liver oil found to possess a significant antioxidant and protective action against inflammation. However, there was no scientific proof established regarding the antiulcer activity of cod liver oil. As inflammation is one the causes of gastric ulcer, the present work was designed to evaluate the anti-ulcer efficiency of cod liver oil in three different ulcerated rat models. Methods: Ulcer was induced through pyloric ligation, ethanol, and aspirin. The effect of Cod liver oil was evaluated by estimating the pH of the gastric juice, volume of gastric juice, ulcer scores, free acidity, total acidity as well as mucin content in the ulcerated rat models. The degree of ulcer protective consequence was explored by comparing the data with standard drugs i.e. omeprazole and sucralfate. Results: Cod liver oil exhibited a significant mucosal protection and anti-secretory action in all three models. Cod liver oil showed percentage ulcer protection of >50% in pyloric ligation, ethanolinduced and aspirin-induced ulcer model when compared to standard drug omeprazole and sucralfate. Conclusion: The findings from the present study indicated that the use of cod liver oil in gastric ulcer may be beneficial as it showed significant mucoprotective and anti-secretory activity in ulcerated rat models.Keywords
Anti-Ulcer, Cod Liver Oil, Pylorus Ligation, Ethanol-Induced Ulcer, Aspirin.References
- Wang Y, Wang S, Lou ZJ, Song XN, Zhang ZY, Li JF, Li S. Anti-ulcer and anti-Helicobacter pylori potentials of the ethyl acetate fraction of Physalis alkekengi L. Var. franchetii (Solanaceae) in rodent. Journal of Ethnopharmacology. 2018; 211: 197-206.
- Amaral GP, De CNR, Barcelos RP, Dobrachinski F, Portella RDL, DaSilva MH, Fachinetto R. Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats. Food and Chemical Toxicology. 2013; 55: 48-55.
- Ishihara M, Kojima R, Ito M. Influence of aging on gastric ulcer healing activities of the antioxidants α-tocopherol and probucol. Europian Journal of Pharmacology. 2008; 601: 143-147.
- Mahattanadul S, Ridtitid W, Nima S, Phdoongsombut N, Ratanasuwon P, Kasiwong S. Effects of Morinda citrifolia aqueous fruit extract and its biomarker scopoletin on reflux esophagitis and gastric ulcer in rats. Journal of Ethnopharmacology. 2011; 134: 243-250.
- Ishihara M, Mikio I. Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. European Journal of Pharmacology. 2002; 444; 209-215.
- Miller JP, Faragher EB. Relapse of duodenal ulcer: Does it matter which drug is used in initial treatment? British Medical Journal (Clinical Research Ed). 1986; 293: 1117-1118.
- Basheer AS, Siddiqui A, Paudel YN, Hassan MQ, Imran M, Najmi AK, Akhtar M. Hepatoprotective and antioxidant effects of fish oil on isoniazid-rifampin induced hepatotoxicity in rats. Pharma Nutrition. 2017; 5: 29-33.
- Berenguer B, Trabadela C, Sánchez-Fidalgo S, Quílez A, Mino P, De LPR, Martín-Calero MJ. The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions. Journal of Ethnopharmacology. 2007; 114: 153-160.
- Junbo Z, Yongtao Y, Hongbo L, Fenshuang Z, Ruyun L, Chunai Y. Experimental study of sucralfate intervention for paraquat poisoning in rats. Environmental Toxicology and Pharmacology. 2017; 53: 57-63.
- Parmar NS, Ghosh MN. Gastric antiulcer activity of (+) cyanidonol-3 a histidine decarboxylase inhibitor”. European Journal Pharmacology 1981; 69: 25-32.
- Birdane FM, Cemek M, Birdane YO, Gulcin I, Buyukokuroglu ME. Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats. World Journal of Gastroenterology. 2007; 13: 607-611.
- Robert A, Nezamis J, Lancaster C, Hanchar A. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology. 1979; 77: 433-43.
- Vogel GH, Vogel WH. Drug Discovery and Evaluation. New York, Berlin: Springer-Verlag; 1997. 2nd ed. pp. 488-489.
- Sanford T. Clinical Diagnosis by Laboratory Methods. Davidson and Henry; 1969. 14th ed. pp. 762-784.
- Sabiu S, Ajani EO, Ajao AA, Sunmonu TO, Ibraheem AS, Ibrahim R, Mustapha H, Adekeye AO. Biomembrane stabilization and antiulcerogenic properties of aqueous leaf extract of Gossypium barbadense L. (Malvaceae). Beni-Suef University Journal of Basic and Applied Sciences. 2017; 6: 301-309.
- Hawk PB, Oser BL, Summerson HW. Practical Physiological Chemistry. London: Churchill. 1947. 12th ed. pp. 347.
- Jainu M, Mohan KV, Devi CSS. Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats. Journal of Ethnopharmacology. 2006; 104: 302-305.
- Lotti VJ, Cerino DJ, Kling PJ, Raymond SL. A new simple mouse model for the in-vivo evaluation of cholecystokinin (CCK) antagonists: comparative potencies and durations of action of nonpeptide antagonists. Life Sciences. 1986; 39(18): 1631-1638.
- Ishii Y. Critical studies of pylorus ligated rat (Shay rat). Japanese Journal of Pharmacology. 1969; 19: 125-133.
- Salim AS. Removing oxygen-derived free radicals stimulates healing of ethanol-induced erosive gastritis in the rat. Digestion. 1990; 4(1): 24-28.
- Salim, AS. Gastric mucosal cytoprotection in the rat by scavenging oxygen-derived free radicals. American Journal of Medical Science. 1991; 302: 287-291.
- Hunkar T, Aktan F, Ceylan A, Karasu C. Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocindiabetic rats. Cell Biochemistry and Function. 2002; 20: 297-302.
- Davenport HW. Is the apparent hypo secretion of acid by patients with gastric ulcer a consequence of a broken barrier to diffusion of hydrogen ions into the gastric mucosa? Gut. 1965; 6(5): 513.
- Davenport HW. Fluid produced by the gastric mucosa during damage by acetic and salicylic acids. Gastroenterology. 1966; 50(5): 487-499.
- Exploring the Protective Effect of Ascorbic Acid on Amoxicillin and Clavulanic Acid-Induced Lipid Peroxidation in Goat Liver Homogenate
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Authors
Affiliations
1 Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh-493111, IN
2 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur, Chhattisgarh,-495009., IN
1 Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh-493111, IN
2 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur, Chhattisgarh,-495009., IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3301-3306Abstract
Background: Therapeutic effect of ascorbic acid on amoxicillin and clavulanic acid-induced lipid peroxidation was carried out in got liver homogenates to investigate the relationship between drug-induced toxicity and drug-induced lipid peroxidation. Methods: The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and the only antioxidant-treated group at two hours and six hours of incubation time. Results: The level of malondialdehyde in the drug-treated group was found to be increased whereas the level of both reduced glutathione and nitric oxide decreased when compared to control. In the drug-antioxidant treated group, the level of malondialdehyde was found to be reduced whereas the extent of reduced glutathione, nitric oxide increased when compared to the drug-treated group. Conclusion: The present study established the potential of amoxicillin and clavulanic acid to induce lipid peroxidation. On the other hand, ascorbic acid repressed lipid peroxidation to a substantial level. Lipid peroxidation initiation capability of amoxicillin and clavulanic acid might be a contributing factor for their toxicity.Keywords
Malondialdehyde, Nitric Oxide, Reduced Glutathione, Lipid Peroxidation, Amoxicillin, Clavulanic Acid, Ascorbic Acid, Antibiotics.References
- Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. London: Lancet. 2000. pp. 1255-1259.
- Cheeseman KH. Mechanisms and effects of lipid peroxidation. Molecular Aspects of Medicine. 1993; 14(3): 191-197.
- Girotti AW. Mechanisms of lipid peroxidation. Journal of Free Radicals Biology Med. 1985; 1(2): 87-95.
- Gurudharshini N, Madhumitha M, Muthusaravanan S, Perianayaki P, Poornimmashree A, Kumaravel K. A big picture on antimicrobial strategies then and now. Research Journal of Engineering and Technology. 2017; 8(4): 361-364.
- Kasapovic J, Pejic S, Stojiljkovic V, Todorovic A, Radosević-Jelic L, Saicic ZS. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. Clinical Biochemistry. 2010; 43(16-17): 1287-1293.
- Selvakumar K, Madhan R, Srinivasan G, Baskar V. Antioxidant assays in pharmacological research. Asian Journal of Pharmacy and Technology. 2011; 1(4): 99-103.
- Karunakar Hegde, Cijo Issac, Arun B. Joshi. Inhibitory Response of Carissa carandas ischolar_main extract on lipid peroxidation. Research Journal of Pharmacy and Technology. 2010; 3 (4): 1072-1076.
- Niki E, Yoshida Y, Saito Y, Noguchi N. Lipid peroxidation: Mechanisms, inhibition, and biological effects. Biochemical and Biophysicxal Research Communication. 2005; 338(1): 668-676.
- Jiby E, Rajesh MG, Anish NP, Deepa P, Jayan N. In vitro antioxidant activity of the methanolic extract of Simaruba glauca DC. Asian Journal of Research in Chemistry. 2010; 3(2): 312-315.
- Dima Al Diab, Nour Al Asaad. Comparative analysis of ascorbic acid content and antioxidant activity of some fruit juices in Syria. Research Journal of Pharmacy and Technology. 2018; 11(2): 515-520.
- Shrada BK, Dhanraj M. Role of Vitamin C in body health. Research Journal of Pharmacy and Technology. 2018; 11(4): 1378-1380.
- Todd PA, Benfield P. Amoxicillin/clavulanic acid: an update of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1990; 39(2): 264-307.
- Gresser U. Amoxicillin-clavulanic acid therapy may be associated with severe side effects-review of the literature, European Journal of Medical Research. 2001; 6(4): 139-149.
- Fontana RJ, Shakil AO, Greenson JK, Boyd I, Lee WM. Acute liver failure due to amoxicillin and amoxicillin/clavulanate. Digestive Diseases and Sciences. 2005; 50(10): 1785-1790.
- Salvo F, Polimeni G, Moretti, Conforti A, Leone R, Leoni O. Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: Data from spontaneous reporting in Italy. Journal of Antimicrobial Chemotherapy. 2007; 60(1): 121-126.
- Cundiff J, Joe S. Amoxicillin-clavulanic acid-induced hepatitis. American Journal of Otolaryngol-Head and Neck Medicine and Surgery. 2007; 28(1): 8-30.
- Garcia Rodriguez LA, Stricker BH, Zimmerman HJ. Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. Archives of Internal Medicine. 1996; 156(12): 1327-1332.
- Muriel P. Role of free radicals in liver diseases. Hepatology International. 2009; 3(4): 526-536.
- Zhu R, Wang Y, Zhang L, Guo Q. Oxidative stress and liver disease. Hepatology Research. 2012; 42(8): 741-749.
- Beattiea D, Sherlock S. Ascorbic acid deficiency in liver disease. Gut.1976; 17(8): 571-575.
- Karunakar H, Cijo I, Arun B. Joshi. Inhibitory response of Carissa carandas ischolar_main extract on lipid peroxidation. Research Journal of Pharmacy and Technology. 2010; 3 (4): 1072-1076.
- Hamid AA, Aiyelaagbe OO, Usman LA, Ameen OM, Lawal A. Antioxidants: its medicinal and pharmacological applications. African Journal of Pure and Applied Chemistry. 2010; 4(8): 142-151.
- Devbhuti P, Saha A, Sengupta C. Gentamicin induced lipid peroxidation and its control with ascorbic acid, Acta Polania Pharmaceutical Drug Research. 2009; 66(4): 363-369.
- Ray S, Roy K, Sengupta C. Cisplatin-induced lipid peroxidation and its inhibition with ascorbic acid. Indian Journal of Pharmaceutical Sciences. 2006; 68(2): 199-204.
- Devbhuti P, Devbhuti, Saha A, Sengupta C. Effect of ascorbic acid on lipid peroxidation induced by ceftazidime. Journal of Pharmaceutical Sciences and Technology. 2011; 1(1): 51-53.
- Ray S. Evaluation of protective role of ascorbic acid on Flutamide-induced lipid peroxidation. International Journal of Pharm Tech Research. 2012; 4(1): 135-140.
- Aruna P, Shruti B, Archana A, Sameer H, Villasrao J. Tobramycin-induced lipid peroxidation and its control with ascorbic acid. Indo American Journal of Pharmaceutical Research. 2013;3(8): 6076-6082.
- Roy K., De AU, Sengupta C. Evaluation of glutathione and ascorbic acid as suppressors of drug-induced lipid peroxidation, Indian Journal of Experimental Biology. 2000; 38(6): 580-586.
- Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomości Lekarskie. 2004; 57(9-10): 453-455.
- Ayala A, Muoz MF, Argelles S. Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine and Cell Longevity. 2014; 2014: 1-31.
- Huda MK, Baydaa ST, Sura AS. Effect of the (ɣ-ray) and laser tadiation on the important antioxidant enzyme glutathione (GSH) level in serum. Research Journal of Pharmacy and Technology. 2017; 10(10): 3386-3390.
- Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. The Journal of Biological Chemsitry. 2003; 278(33): 31426-31433.
- Ferreira ALA, Machado PEA, Matsubara LS. Lipid peroxidation, antioxidant enzymes and glutathione levels in human erythrocytes exposed to colloidal iron hydroxide in vitro. Brazilian Journal of Medicine and Biological Reearch. 1999; 32(6): 689-694.
- Hogg N, Kalyanaraman B. Nitric oxide and lipid peroxidation. Biochimica Et Biophysica Acta. 1999; 1411(2-3): 378-384.
- Hilditch TP. The chemical constituents of natural fats. Champel and Hall Ltd. London. 1956, 3rd ed. pp. 664.
- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry. 1979; 95(2): 351-358.
- Sun J, Zhang X, Broderick M, Fein H. Measurement of nitric oxide production in biological systems by using griess reaction assay. Sensors. 2003; 3(8): 276-284.
- Supratim Ray. Exploring the protective role of water extract of Spirulina platensis on flutamide-induced lipid peroxidation using 4-Hydroxy nonenal and nitric oxide as model markers. Research Journal of Pharmacy and Technology. 2011; 4(12): 1857-1860.
- Ellman GL. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics. 1959; 82(1): 70-77.
- Ray S. Exploring the protective role of ascorbic acid on Busulfan-induced lipid peroxidation. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2011; 2(4): 702-708.
- Joseph PR, Paul B. Remington: The science and practice of pharmacy. In: Statistics. Lippincott Williams & Wilkins, Philadelphia 2006. 21st ed. pp. 127-150.
- Balakrishnan N, Panda A B, Raj N R, Shrivastava A, Prathani R. The Evaluation of Nitric Oxide Scavenging Activity of Acalypha Indica Linn Root. Asian Journal of Research in Chemistry. 2009; 2(2): 148-150.